Biotransformation Director

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: June 24, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Purpose: The Director of Biotransformation will scientifically manage Discovery and Development biotransformation activities and staff for small molecules and new modalities within the ADME/Tox organization. The director will provide deep scientific and strategic direction, ensuring that all activities are aligned with the organization's goals. This role involves assembling and managing a team of experts in biotransformation supporting drug metabolism, pharmacokinetics and fostering collaboration and innovation across multiple sites. The director will be responsible for maintaining high-quality data, implementing best practices, and ensuring compliance in and influencing regulatory guidance across both discovery and development. They will also work closely with other ADME/Tox staff, and other departments to integrate biotransformation insights into broader research and development strategies. The Director will represent Eli Lilly and Company in external collaborations, conferences, and industry forums, contributing to the advancement of knowledge in the field. Ultimately, this leadership role is essential for driving scientific excellence and strategic growth within the biotransformation group, ensuring that our drug discovery and development efforts are efficient, innovative, and impactful. Responsibilities: Help build/cultivate a team of biotransformation scientists to support Discovery and Development projects for small molecules and new modalities. Lead biotransformation team in designing and implementing biotransformation studies both internally and externally at CROs. Ensure high-quality data is generated by both internal and external sources. Understand, influence and apply regulatory guidance relevant to biotransformation/metabolism studies. Develop and implement strategic plans for biotransformation project support. Communicate the interpretation and impact of biotransformation results across ADME/Tox, project teams, and management effectively. Collaborate in a fast-paced work environment with internal staff and external CROs. Mentor and supervise junior staff. Engage in the external scientific community. Minimum Qualifications: PhD in chemistry, or related field with 7 years of work experience in biotransformation and drug metabolism. Additional Qualifications/Attributes: Demonstrated experience supporting biotransformation/bioanalysis of new modalities (i.e. ADC’s, peptides, RNA, siRNA, ARC’s). Strong leadership, communication, and interpersonal skills. Experience with regulatory guidance(s) for drug development. Experience managing scientific teams Deep understanding of biotransformation, and drug metabolism impact on moving compounds from Discovery though IND to NDA Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $168,000 - $294,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: Eli Lilly and Company, Lawrence , Biotransformation Director, Science, Research & Development , Indianapolis, Indiana