Principal Architect - MES
Location: Indianapolis
Posted on: June 23, 2025
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Job Description:
At Lilly, we unite caring with discovery to make life better for
people around the world. We are a global healthcare leader
headquartered in Indianapolis, Indiana. Our employees around the
world work to discover and bring life-changing medicines to those
who need them, improve the understanding and management of disease,
and give back to our communities through philanthropy and
volunteerism. We give our best effort to our work, and we put
people first. We’re looking for people who are determined to make
life better for people around the world. Sr. Principal Architect -
MES This is an opportunity you don’t want to miss! At Lilly, we
serve an extraordinary purpose. We make a difference for people
around the globe by discovering, developing, and delivering
medicines that help them live longer, healthier, more active lives.
Not only do we deliver breakthrough medications, but you also can
count on us to develop creative solutions to support communities
through philanthropy and volunteerism. Lilly is entering an
exciting period of growth, and we are committed to delivering
innovative medicines to patients around the world. Lilly is
investing around the world to create new state-of-the-art
manufacturing site’s and continue expanding our existing facilities
to created capacity required to continue with our mission. The
brand-new facilities will utilize the latest technology, advanced
highly integrated and automated manufacturing systems, and have a
focus on minimizing the impact to our environment. The Tech@Lilly
MQ team at the Indianapolis Parenteral Manufacturing site is
actively looking for a Senior Architect for Manufacturing Execution
Systems (MES). Are you passionate about manufacturing excellence
and applying technology to make reliable and life-saving medicines?
Are you wanting to work in to work in a diverse and inclusive,
fast-paced and dynamic environment? If so, bring YOUR skills and
talents to Lilly where you’ll have the chance to create an impact
on the lives of patients with “Safety First and Quality Always”.
What You’ll Be Doing: As the Senior MES Architect, your main
responsibility will be to craft and develop robust IT architecture
solutions tailored to sophisticated business challenges within the
pharmaceutical manufacturing domain. This role demands a deep
technical expertise in creating integrated process, application,
data, and technology architectures, ensuring conformity with
enterprise standards and strategic goals. At the Indy Parenteral
Manufacturing (IPM) you will help lead the implementation of
complex MES, driving the transition from PMX to PharmaSuite. Your
role will involve deploying innovative technologies, while ensuring
sustainability and robustness of existing manufacturing and
warehouse systems, as well as collaborating multi-functionally to
uphold the Manufacturing Strategy for Operational Excellence. You
will be instrumental in delivering IT solutions that meet exacting
quality standards and facilitate the site’s mission and vision. How
You Will Succeed: Bring your deep technical knowledge and
experience to design and develop product architecture for MES and
Digital Execution solutions. Provide technical support and
troubleshooting for manufacturing systems, including MES,
automation, and IT infrastructure. Diagnose and resolve issues
related to equipment, software, and network connectivity to
minimize production downtime. Collaborate with cross-functional
teams, including engineering, operations, and quality, to identify
root causes and implement corrective actions. Must ensure the
compatibility, integration, interoperability, stability,
scalability and usability of products/services proposed as
standards to ensure an integrated architecture across
interdependent technologies. Must serve as a technical expert on
solutions design, development, and implementation requirements to
address business needs. Must consider security, privacy and data
integrity risks and design IT systems that are secure and protect
company data and ensure compliance. Possess the capability to
communicate sophisticated technical information to both technical
and non-technical partners and influence decision making at senior
leadership level. Develop an in-depth understanding of the business
processes at IPM. Apply knowledge to assigned solutions to support
the operational workflow. Work with Process Engineers, Operations,
Quality, and Scientists to resolve any issues reported on the
solutions implemented. Drive the site adoption of assigned
solutions, ensuring consistency with Site and IT strategy, and
using awareness of internal and external trends in collaboration
with the Business SMEs. Collaborate with developers and subject
authorities (global and local) to establish the technical vision
and analyze trade-offs between usability and performance needs.
Review and approve documentation related to areas of responsibility
(Validation Lifecycle documents, SOPs, policies, implemented IQPQ
protocols, etc.) as appropriate. What You Should Bring: Experience
with designing and developing IT architecture (integrated process,
applications, data and technology) and solutions to business
problems in alignment with the enterprise architecture direction
and standards. Experience leading or supporting the Computer System
Validation of IT platforms including Data Integrity compliance.
Experience with identifying system requirements, such as
performance, scalability, security, compatibility,
interoperability, stability, usability, data integrity and ensure
that these requirements are met within the overall system
architecture. Experience with providing technical guidance to other
members of the organization, including developers, project
managers, and technical support staff. Staying up to date with
industry trends and emerging technologies to ensure that the
organization's systems remain innovative and effective. Superb
communication and people skills to build relationships with team
members and articulate sophisticated technical concepts.
Adaptability and flexibility to work in a fast-paced, dynamic
environment and lead multiple tasks simultaneously. Demonstrable
experience in platform practices and procedures such as
infrastructure qualification, patching, monitoring, log analysis,
edge computing, site reliability engineering, or disaster recovery.
Consistent track record in tools / platforms such as MES (PMX,
PharmaSuite, and/or Syncade) as well as WES/SAP, along with
integration technologies enabling data flow with downstream and
upstream systems (e.g. SAP, LIMS, MQTT, PI, Data Lakes, Process
Monitoring systems such as JMP, Tableau, Power BI) Develop or
update project plans including the determination of project
activities and achievements. Provided oversight of multiple project
and communications status. Your Basic Qualifications: Bachelor’s
degree in Software Engineering, Computer Science, Computer
Engineering, or a related field. Minimum of 6 years of experience
working with Pharmaceutical Manufacturing Execution Systems,
specifically PMX, PharmaSuite, and/or Syncade as well as WES/SAP.
Minimum of 6years of experience on pharmaceutical manufacturing
facilities Extensive background with MES and how to integrate with
Warehouse, Automation, Lab and other Local/Global IT platforms.
Additional Information: Technology experience including Windows OS,
Linux OS, Oracle SQL, Microsoft SQL Server, Citrix, Kepware,
ServiceNow. Experience maintaining Computer Systems Validation in
line with pharmaceutical computer system quality regulations (e.g.
cGMP’s, FDA 21 CFR Part 11) and other applicable regulations (e.g.
privacy, OSHA, etc.). This position will be on site 4 days a week
Potential travel and after-hours work Lilly is dedicated to helping
individuals with disabilities to actively engage in the workforce,
ensuring equal opportunities when vying for positions. If you
require accommodation to submit a resume for a position at Lilly,
please complete the accommodation request form (
https://careers.lilly.com/us/en/workplace-accommodation ) for
further assistance. Please note this is for individuals to request
an accommodation as part of the application process and any other
correspondence will not receive a response. Lilly is proud to be an
EEO Employer and does not discriminate on the basis of age, race,
color, religion, gender identity, sex, gender expression, sexual
orientation, genetic information, ancestry, national origin,
protected veteran status, disability, or any other legally
protected status. Our employee resource groups (ERGs) offer strong
support networks for their members and are open to all employees.
Our current groups include: Africa, Middle East, Central Asia
Network, Black Employees at Lilly, Chinese Culture Network,
Japanese International Leadership Network (JILN), Lilly India
Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ
Allies), Veterans Leadership Network (VLN), Women’s Initiative for
Leading at Lilly (WILL), enAble (for people with disabilities).
Learn more about all of our groups. Actual compensation will depend
on a candidate’s education, experience, skills, and geographic
location. The anticipated wage for this position is $63,750 -
$180,400 Full-time equivalent employees also will be eligible for a
company bonus (depending, in part, on company and individual
performance). In addition, Lilly offers a comprehensive benefit
program to eligible employees, including eligibility to participate
in a company-sponsored 401(k); pension; vacation benefits;
eligibility for medical, dental, vision and prescription drug
benefits; flexible benefits (e.g., healthcare and/or dependent day
care flexible spending accounts); life insurance and death
benefits; certain time off and leave of absence benefits; and
well-being benefits (e.g., employee assistance program, fitness
benefits, and employee clubs and activities).Lilly reserves the
right to amend, modify, or terminate its compensation and benefit
programs in its sole discretion and Lilly’s compensation practices
and guidelines will apply regarding the details of any promotion or
transfer of Lilly employees. WeAreLilly
Keywords: , Lawrence , Principal Architect - MES, IT / Software / Systems , Indianapolis, Indiana
